This small volume is intended to provide the essential core knowledge required to assess patients with possible disorders of the blood, organise relevant investigations and initiate therapy where necessary. By reducing extraneous information as much as possible, and presenting key information for each topic, a basic understanding of the pathophysiology is provided and this, we hope, will stimulate readers to follow this up by consulting the larger haematology textbooks.
1 Clinical approach 1 2 Red cell disorders . 43 3 White blood cell abnormalities 133 4 Leukaemia . 149 5 Lymphoma . 193 6 Myelodysplasia 217 7 Myeloproliferative disorders . 237 8 Paraproteinaemias . 265 9 Transplantation . 293 10 Haemostasis and thrombosis 343 11 Immunodeficiency . 407 12 Paediatric haematology . 421 13 Haematological emergencies 499 14 Supportive care . 535 15 Protocols and procedures 543 16 Haematological investigations 631 17 Blood transfusion 643 18 Phone numbers and addresses . 663 19 Haematology on-line . 671 20 Charts and nomograms . 677 21 Normal ranges 687
Clinical approach 1 History taking in patients with haematological disease . 2 Physical examination 4 Splenomegaly 6 Lymphadenopathy 8 Unexplained anaemia 10 Patient with elevated haemoglobin . 12 Elevated WBC . 14 Reduced WBC . 16 Elevated platelet count 20 Reduced platelet count 22 Easy bruising . 24 Recurrent thromboembolism . 26 Pathological fracture 28 Raised ESR 30 Serum or urine paraprotein 32 Anaemia in pregnancy . 34 Thrombocytopenia in pregnancy 36 Prolonged bleeding after surgery 38 Positive sickle test (HbS solubility test) . 40
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